abstract：:Hippurate had antitumor effects both in vitro and in vivo by killing dose-dependently the cells derived from Skalsky lymphoma, Németh-Kellner lymphoma, L-asparaginase sensitive 6C3HED Gardner lymphoma, and LP-2 plasmacytoma. There was no significant difference between the effect of hippurate and its maternal compound ...

journal_title：Neoplasma

authors： Spustová V,Oravec C

更新日期：1989-01-01 00:00:00

abstract：:The level of lipid-bound sialic acid (LSA) was followed in inbred C57Bl/6 mice bearing tumors induced by benzpyrene at a dose of 20 mg per kg of body weight. In the plasma of mice with macroscopically ascertained tumors, the level of LSA was increased significantly. The LSA level was also significantly increased in th...

journal_title：Neoplasma

authors： Polívková J,Vosmiková K,Pospísil J

更新日期：1989-01-01 00:00:00

abstract：:The influence of hypothyroidism on AFB1 carcinogenesis in inbred Wistar rats was studied. The primary AFB1 hepatocarcinogenesis was significantly delayed and reduced. The transplantable hepatomas showed prolonged latency periods in rats of both sexes, and in males decreased tumor weights and a lower number of lung met...

journal_title：Neoplasma

authors： Bednarz W

更新日期：1989-01-01 00:00:00

abstract：:Effect of tumor growth on the survival of circulating erythrocytes was studied in mice bearing a wide spectrum of experimental tumors. RBC half-life (t1/2), measured by 51Cr-labeling technique, decreased significantly (p less than 0.05) in all the tumor types studied, particularly in transplantable Sarcoma-180 and ben...

journal_title：Neoplasma

authors： Ray MR,Chowdhury JR

更新日期：1989-01-01 00:00:00

abstract：:In a series of 25 patients with cervical carcinoma and 35 patients with vulvar carcinoma, clinically classified (FIGO) as Stage I and Ib, respectively, DNA ploidy and S-phase cell fraction were estimated in paraffin-embedded samples of the primary tumors and their metastases by means of flow cytometry (FCM). The two g...

journal_title：Neoplasma

authors： Siracký J,Kysela B,Siracká E

更新日期：1989-01-01 00:00:00

abstract：:A patient with a seven-year history of polycythemia vera treated by repeated phlebotomies and intermittent busulfan administration developed gradually lymphocytosis accompanied by thrombocytopenia in peripheral blood and in the bone marrow. A marked pathological monoclonal proliferation of the B-cell population was de...

journal_title：Neoplasma

authors： Koza I,Babusíková O

更新日期：1988-01-01 00:00:00

abstract：:Lectin dependent cell mediated cytotoxicity (LDCC) to autologous tumor cells (ATC) by the tumor associated macrophages (TAM) was studied by 4 h 51Cr release assays at early and late stages of growth of a murine transplantable ascites tumor, S-180, in presence of different concentrations of wheat germ agglutinin (WGA) ...

journal_title：Neoplasma

authors： Chattopadhyay U,Bhattacharyya S

更新日期：1988-01-01 00:00:00

abstract：:The age of patients, type of tumor growth, pretreatment hematocrit, and radiation-induced tumor regression were evaluated as possible prognostic factors in 222 patients with advanced cervical cancer treated at the Institute of Clinical Oncology in Bratislava in the period from 1960 through 1980. The five-year disease-...

journal_title：Neoplasma

authors： Boljesíková E,Gyárfásová M,Durkovský J

更新日期：1988-01-01 00:00:00

abstract：:Using the model of Sarcoma I (SaI) (H-2a) tumor allograft transplanted to normal B10 (H-2b) mice and to B10 mice pretreated with ATS, we studied the effects of anti-Thy-1,2 monoclonal antibody (MTA) and compared them with those of rabbit polyvalent antiserum against mouse thymocytes (ATS). When administered shortly be...

journal_title：Neoplasma

authors： Sobotková E,Sůla K,Nouza K

更新日期：1988-01-01 00:00:00

abstract：:The histochemical properties of mucus in 48 diffuse type gastric carcinomas and in 46 intestinal type gastric cancers were investigated. In the diffuse type there was a prevalence of intracellular secretion of mucopolysaccharides with a significantly larger portion of sulfated mucopolysaccharides. Acid mucopolysacchar...

journal_title：Neoplasma

authors： Tichá V,Jansa P,Tichý M

更新日期：1988-01-01 00:00:00

abstract：:We report on 12 patients who fulfilled the FAB diagnosis criteria of chronic myelomonocytic leukemia (CMML). Some clinical findings (splenomegaly) as well as biological parameters (WBC count, cellularity of bone marrow sections, presence of dyserythropoiesis in bone marrow smears) were subjected to particular analysis...

journal_title：Neoplasma

authors： Yavòrkovsky LL,Solovei DY,Ryauzova LY,Schvidel LM,Zile MA,Sused SG,Teilane IY

更新日期：1988-01-01 00:00:00

abstract：:The review of the literature assessing the value of external radiotherapy in treatment of patients with prostatic cancer is presented. Radiotherapy appears to be the curative treatment since about 55% of 10 years symptoms free survival rate can be achieved in stages A and B and 35% in stage C. The results of radiother...

journal_title：Neoplasma

authors： Korzeniowski S

更新日期：1988-01-01 00:00:00

abstract：:Inaccuracy, inadequate use of histooncological diagnosis and deficient use of the diagnostic scope have been found in our set of examinations. Responsibility for diagnostic errors resided most frequently in poor knowledge of the problem. Therefore more consistent postgraduate training in histooncological classificatio...

journal_title：Neoplasma

authors： Bednár B

更新日期：1988-01-01 00:00:00

abstract：:The serum concentrations of immunosuppressive acidic protein (IAP), CA 125, alpha-1-antitrypsin (AL-1-AT), C-reactive protein (CRP) and ceruloplasmin (COP) were determined in 63 patients with ovarian carcinoma (mean age 56.9 +/- 11.1 years). The threshold value of IAP was 640 micrograms/ml (means + 2SD), of CA 125 35 ...

journal_title：Neoplasma

authors： Koebl H,Tatra G,Bieglmayer C

更新日期：1988-01-01 00:00:00

abstract：:Rearrangement and loss of genetic material in DNA of human ductal breast carcinoma was analyzed by restriction enzyme digestion, agarose gel electrophoresis and Southern blot hybridization using 32P labeled c-Ha-ras-1 and multilocus, minisatellite 15.1.11.4 as a probe. In several cases an allelic loss of c-Ha-ras-1 lo...

journal_title：Neoplasma

authors： Mackiewicz M,Choina B,Kadlof A,Szala S

更新日期：1988-01-01 00:00:00

abstract：:A group of 54 patients with the original diagnosis of polycythemia vera were subjected to cytogenetic examination. Six (17.6%) of the 34 cases examined in the period of the advanced phase of the polycythemia vera had a chromosomal change. Thirteen (65%) of the 20 patients undergoing the cytogenetic examination in the ...

journal_title：Neoplasma

authors： Jarosová M,Indrák K,Dusek J,Kapustová M

更新日期：1988-01-01 00:00:00

abstract：:The influence of 13-cis-retinoic acid on the light-caused injury of hematoporphyrin-pretreated nontransformed 10 T1/2 fibroblasts and N2a neuroblastoma cells was investigated. Retinoid reduced the percentage of damaged cells as assessed by the plating efficiency assay. N2a neuroblastoma cells were found to be better p...

journal_title：Neoplasma

authors： Szaniawska B,Janik P,Ostrowski J,Graczyk A

更新日期：1988-01-01 00:00:00

abstract：:The purpose of the present paper was to demonstrate the antitumor activity of lymphocytes and antibodies in the antibody-dependent cell-mediated cytotoxicity test (ADCC) in relation to the tumor growth in adult and aging rats bearing a methylcholanthrene-induced sarcoma (MC-Sa). In the syngeneic system using the ADCC ...

journal_title：Neoplasma

authors： Nowak JJ,Ziółkowska M,Ryzewska A

更新日期：1987-01-01 00:00:00

abstract：:In a group of 11,153 autopsied subjects a higher number of cholecystectomies was found in both sexes in individuals with large intestine tumors as compared with the rest of the autopsied persons without tumors (p less than 0.001). The results confirmed the hypothesis that cholecystectomy is a supporting factor in the ...

journal_title：Neoplasma

authors： Hladík V,Nozicka Z,Maslowská H

更新日期：1987-01-01 00:00:00

abstract：:Some results of the first more complex studies in vitro on radio-sensitizing efficiency, cytotoxicity and reactivity with blood-thiols of a series of 4- or 5-nitroimidazoles substituted in the 5, 4 or 2 position with chlorine are presented. The derivatives of 4-nitroimidazole substituted in 5 position ("ortho" positio...

journal_title：Neoplasma

authors： Wideł M,Watras J,Suwiński J,Salwińska E

更新日期：1987-01-01 00:00:00

abstract：:By the use of the dextran-coated charcoal method the presence of a high-affinity binding site for benzo(a)pyrene in the cytosol from rat liver (R strain) has been demonstrated. This binder was saturable by ligand concentration and by time. Sucrose density gradient analysis after charcoal treatment revealed one major p...

journal_title：Neoplasma

authors： Mureşan Z,Stoica A,Stafidov N,Voiculetz N

更新日期：1987-01-01 00:00:00

abstract：:Eighty-eight patients with histologically confirmed colon cancer and two control groups individually matched by age, sex and place of residence, were interviewed about demographic, biosocial and medical variables. The use of laxatives, past history of large bowel disease and coffee consumption for 20 or more years wer...

journal_title：Neoplasma

authors： Vlajinac H,Jarebinski M,Adanja B

更新日期：1987-01-01 00:00:00

abstract：:A comparison of the absolute numbers of leukocytes, proportions, and absolute numbers of various lymphocyte populations in patients with precancerous lesions and cancer of the oral cavity along with normal controls was carried out. Total leukocytes and lymphocytes showed reduction in their numbers in the patient group...

journal_title：Neoplasma

authors： Pillai MR,Balaram P,Abraham T,Nair MK

更新日期：1987-01-01 00:00:00

abstract：:In 115 patients with chronic lymphocytic leukemia (CLL), grouped according to the staging system as proposed by Rai et al., dipeptidylpeptidase II (DPP II) reaction was carried out in smears of peripheral blood using Lys-Pro-MNA and Lys-Ala-MNA as substrates and Fast Blue B (FBB) as the coupling agent in cacodylate bu...

journal_title：Neoplasma

authors： Klener P,Lojda Z,Háber J,Kvasnicka J

更新日期：1987-01-01 00:00:00

abstract：:The significance of CEA, AFP, HCG and SP1 determinations in 85 patients with ovarian cancer were analyzed from the point of view of evaluation of the clinical status of the patients. On the basis of the trials it was stated that a satisfactory correlation between the extension of the tumor and the serum CEA level was ...

journal_title：Neoplasma

authors： Pulay T,Csömör S,Mészáros K,Szarka G,Csabay L,Szinnyai A

更新日期：1987-01-01 00:00:00

abstract：:In 41 patients with Hodgkin's disease nitroblue tetrazolium (NBT) dye reduction with resting and stimulated granulocytes, before, in the course and after chemotherapy was examined. Twofold decrease of the capability of NBT reduction test with stimulated granulocytes was found, whereas with resting granulocytes only sl...

journal_title：Neoplasma

authors： Kemona H,Wysocka J,Prokopowicz J,Kiluk S

更新日期：1987-01-01 00:00:00

abstract：:In the blood of 39 women with endometrial carcinoma the FSH, LH, estrone, androstendion, estradiol and dehydroepiandrosterone were determined by the RIA method. Compared to the control group the estrone (303.3 +/- 44.3 pmol/l), estradiol (165.2 +/- 29.4 pmol/l) and the androstendion (5.24 +/- 0.44 nmol/l) were signifi...

journal_title：Neoplasma

authors： Gimes G,Szarvas Z,Siklósi G

更新日期：1986-01-01 00:00:00

abstract：:IgA1-2 subclass distribution was determined in a series of 62 sera with diagnosed IgA paraprotein. Throughout the series the participation of IgA1 : IgA2 subclasses showed a ratio 9 : 1 even after division of the series into myeloma and nonmyeloma paraproteinemias. On dividing the series according to the antigenic typ...

journal_title：Neoplasma

authors： Tichý M,Hrncír Z

更新日期：1986-01-01 00:00:00

abstract：:Genetic background of high incidence of spontaneous tumors in BDX rats was investigated with respect to susceptibility to physical or chemical agents and immune response. Percentages of colony forming ability of normal embryo fibroblasts from BDX rats after exposure to various doses of ultraviolet (UV) light, X-rays a...

journal_title：Neoplasma

authors： Oikawa T,Koga Y,Tanahashi K,Saito T,Kobayashi H,Kuzumaki N

更新日期：1986-01-01 00:00:00

abstract：:Surgical specimens from two patients with simultaneously occurring ovarian and endometrial endometrioid carcinoma were studied by flow cytometry (FCM) and routine histological examination. Tissue derived from the uterine and the ovarian lesion showed similar FCM curves in each case. The information obtained from FCM w...

journal_title：Neoplasma

authors： Vassilev NB,Christov KT,Raychev RD

更新日期：1986-01-01 00:00:00

abstract：:Flow cytometry (FCM) was introduced for estimation of DNA content in 75 brain tumors. Among these astrocytomas (38 cases) and meningiomas (16 cases) predominated. Astrocytomas were histologically subdivided into 3 groups of malignancy grade. Aneuploid cell populations were found in 1 out of 4 cases of astrocytoma grad...

journal_title：Neoplasma

authors： Christov K,Zapryanov Z

更新日期：1986-01-01 00:00:00

abstract：:Forty-four cases of well documented progressive radiation myelopathy of thoracic spinal cord were analyzed in terms of the new DFT conception (Dose-Fraction-Time). The DFT conception is a new radiobiological cell tissue kinetic model comprising explicitly repopulation. The conception has been previously tested against...

journal_title：Neoplasma

authors： Vodvárka P,Kozubek S

更新日期：1986-01-01 00:00:00

abstract：:Cytogenetic studies were carried out in peripheral blood lymphocytes of 31 children with cancer (12 retinoblastomas, 9 non-Hodgkin's lymphomas, 7 neuroblastomas and 3 Wilms' tumors) with the purpose of investigating the prevalence and persistence of chromosomal aberrations before onset of antineoplastic treatment and ...

journal_title：Neoplasma

authors： García J,Ruisánchez N,Longchong M,Valdés M,Puig M,Menéndez J,Alert J,Ramos S

更新日期：1986-01-01 00:00:00

abstract：:Mitoxantrone, a new anticancer drug has DNA-binding properties similar to anthracycline antibiotics. In the present studies, effect of the drug has been tested in vitro on human chronic myeloid leukemia cells at 37 degrees C and 42 degrees C. Inhibition of 3H-tritiated thymidine incorporation in the drug-treated cells...

journal_title：Neoplasma

authors： Juvekar AS,Chitnis MP,Adwankar MK,Advani SH

更新日期：1986-01-01 00:00:00

abstract：:The relationship of pretreatment immunologic status in terms of skin tests to prognosis within stages was studied in 152 breast cancer patients. DNCB and PPD testing was used. As for DNCB, no relationship was found at early stages of the disease. In locoregionally advanced disease, patients with stronger test grades h...

journal_title：Neoplasma

authors： Munzarová M,Kovarík J,Hlávková J,Popelínský L,Lauerová L

更新日期：1985-01-01 00:00:00

abstract：:The concentration of estradiol and progesterone receptors in tumor cytosol from human breast cancer patients represents an important factor for the selection of patients for endocrine therapy and for the prognosis of the disease. This report presents results obtained by measurement of estradiol receptor in 157 breast ...

journal_title：Neoplasma

authors： Mureşan Z,Voiculetz N

更新日期：1985-01-01 00:00:00

abstract：:To understand the nature of copper distribution during malignancy, 27 strains A/RB mice with fibrosarcoma were used. Tracer methodology with radioactive isotope of copper (64Cu) was applied. In the study made at different time intervals after isotope administration whole blood plasma and different tissues like liver, ...

journal_title：Neoplasma

authors： Chakravarty PK,Ghosh A,Chowdhury JR

更新日期：1985-01-01 00:00:00

abstract：:Weanling ICRC female mice were given syngeneic neonatal thymus graft under renal capsule and two weeks later whole-body gamma-radiation (group ITR). The findings on ITR were compared with three controls--untreated (C), thymus grafted (IT) and irradiated (IR). In ITR group 15/15 developed generalized neoplasms of retic...

journal_title：Neoplasma

authors： Pai SR,Sequeira B

更新日期：1985-01-01 00:00:00

abstract：:A comparison of efficacies of medroxyprogesterone acetate (MPA) and the antiestrogen tamoxifen (TX) in the therapy for advanced breast cancer in patients who had already previously been intensely treated showed that, as to the objective remissions, the two drugs can be looked upon as equivalent. Nevertheless, with MPA...

journal_title：Neoplasma

authors： Lorenz I,Mechl Z

更新日期：1985-01-01 00:00:00

abstract：:Forty-five thousand three hundred thirteen patients treated in our Institute during the period 1949-1982 were retrospectively analyzed in regard to the appearance of secondary tumors after therapy. Eighty-seven (0.19%) tumors were found, 71 (81.6%) being secondary and 16 (18.4%) simultaneous. Fifty-one (71.8%) tumors ...

journal_title：Neoplasma

authors： Svejda J,Lorenz I

更新日期：1985-01-01 00:00:00